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Product Name
Phospho-IRS1 (Ser312) Rabbit pAb
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Gene ID
3667
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SwissProt ID
P35568
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Gene Name
IRS1
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Alternative Names
IRS1 (phospho S312); IRS-1 (Phospho-Ser312); p-IRS1; IRS1(phospho-Ser789); IRS1_HUMAN; Insulin receptor substrate 1; IRS-1; IRS 1;
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Background
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit .
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Research Field
Tags & Cell Markers
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Rat
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Application
IHC-P,FC,ELISA
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Dilution Ratio
IHC: 1/50-1/100 ELISA: 1/5000-1/10000
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Molecular Weight
Calculated MW: 132kDa
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Clonality
Polyclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
KLH conjugated Synthesised phosphopeptide derived from human IRS1 around the phosphorylation site of Ser312
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Purification
affinity purified by Protein A
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.