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Product Name
Phospho-JAK2 (Tyr221) Rabbit pAb
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Gene ID
3717
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SwissProt ID
O60674
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Gene Name
JAK2
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Alternative Names
JAK2 (phospho Y221); p-JAK2 (phospho Tyr221); Tyrosine protein kinase JAK2; JAK 2; JAK-2; JAK2; JAK2_HUMAN; Janus Activating Kinase 2; Janus Kinase 2; JTK 10; JTK10; OTTHUMP00000043260; Tyrosine-protein kinase JAK2; Tyrosine protein kinase JAK2.
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Background
Phosphorylated STATs then form homodimer or heterodimers and translocate to the nucleus to activate gene transcription. For example, cell stimulation with erythropoietin (EPO) during erythropoiesis leads to JAK2 autophosphorylation, activation, and its association with erythropoietin receptor (EPOR) that becomes phosphorylated in its cytoplasmic domain. Then, STAT5 (STAT5A or STAT5B) is recruited, phosphorylated and activated by JAK2.
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Zebrafish
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Application
IHC-F,IHC-P,ICC/IF,FC,ELISA
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Dilution Ratio
IHC: 1/50-1/100 IF: 1/50-1/200 ELISA: 1/5000-1/10000
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Molecular Weight
Calculated MW: 131kDa
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Clonality
Polyclonal Antibody
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Clonality No.
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Isotype
IgG
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Immunogen
KLH conjugated synthesised phosphopeptide derived from human JNK2 around the phosphorylation site of Tyr221
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Purification
affinity purified by Protein A
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
Liquid
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Buffer System
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
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Storage
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.