-
Product Name
Phospho-Bax (Ser184) Rabbit pAb
-
Gene ID
581
-
SwissProt ID
Q07812
-
Gene Name
BAX
-
Alternative Names
Bax (phospho S184); Bax (phospho Ser184); p-Bax (S184); p-Bax (Ser184); apoptosis regulator BAX; Apoptosis regulator BAX cytoplasmic isoform beta; Apoptosis regulator BAX membrane isoform alpha; Bax isoform psi; BAX protein cytoplasmic isoform delta; Bax protein cytoplasmic isoform delta. antibody Bax protein cytoplasmic isoform gamma; Bax zeta; Bax-protein; Bcl-2-like protein 4; BCL2 associated X protein; BCL2L4; BAX_HUMAN; Bcl2-L-4.
-
Background
Bax is a key component for cellular induced apoptosis through mitochondrial stress. Upon apoptotic stimulation, Bax forms oligomers and translocates from the cytosol to the mitochondrial membrane. Through interactions with pore proteins on the mitochondrial membrane, Bax increases the membrane's permeability, which leads to the release of cytochrome c from mitochondria, activation of caspase-9 and initiation of the caspase activation pathway for apoptosis.
-
Research Field
Cell Biology
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse,Rat
-
Application
WB,IHC-P,FC,ELISA
-
Dilution Ratio
WB: 1/500-1/1000 IHC: 1/50-1/100 ELISA: 1/5000-1/10000
-
Molecular Weight
Calculated MW: 21kDa
-
Clonality
Polyclonal Antibody
-
Clonality No.
-
-
Isotype
IgG
-
Immunogen
KLH conjugated Synthesised phosphopeptide derived from human Bax around the phosphorylation site of Ser184
-
Purification
affinity purified by Protein A
-
Conjugation
Unconjugated
-
Modification
Phosphorylated
-
Form
Liquid
-
Buffer System
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
-
Storage
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.