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Product Name
Phospho-IP3R1 (Ser1764) Rabbit pAb
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Gene ID
3708
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SwissProt ID
Q14643
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Gene Name
ITPR1
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Alternative Names
Inositol 1,4,5-trisphosphate receptor type 1; InsP3R1; IP3 receptor isoform 1; IP3R; ITPR1; Type 1 inositol 1,4,5- trisphosphate receptor; Type 1 InsP3 receptor
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Background
Inositol 1,4,5-trisphosphate-gated calcium channel that, upon inositol 1,4,5-trisphosphate binding, mediates calcium release from the endoplasmic reticulum (ER) (PubMed:10620513, PubMed:27108797).
Undergoes conformational changes upon ligand binding, suggesting structural flexibility that allows the channel to switch from a closed state, capable of interacting with its ligands such as 1,4,5-trisphosphate and calcium, to an open state, capable of transferring calcium ions across the ER membrane (By similarity).
Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CAMK2 complex (By similarity).
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Research Field
Neuroscience
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
IHC-P
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Dilution Ratio
IHC: 1/50-1/100
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Molecular Weight
Calculated MW: 313 kDa
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Clonality
Polyclonal Antibody
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Isotype
IgG
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Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human IP3R1 around the phosphorylation site of serine 1764 (R-E-SP-L-T).
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
liquid
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Buffer System
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.