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Product Name
Phospho-LIMK2 (Ser283) Rabbit pAb
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Gene ID
3985
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SwissProt ID
P53671
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Gene Name
LIMK2
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Alternative Names
EC 2.7.11.1; kinase LIMK2; LIM domain kinase 2; LIMK-2
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Background
Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics (PubMed:10436159, PubMed:11018042).
Acts downstream of several Rho family GTPase signal transduction pathways (PubMed:10436159, PubMed:11018042).
Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP (PubMed:22328514).
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Research Field
Neuroscience
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
IHC-P
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Dilution Ratio
IHC: 1/50-1/100
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Molecular Weight
Calculated MW: 72 kDa
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Clonality
Polyclonal Antibody
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Isotype
IgG
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Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human LIMK2 around the phosphorylation site of serine 283 (R-R-SP-L-R).
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
liquid
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Buffer System
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.