-
Product Name
Phospho-CAMK2-β/γ/δ (Thr287) Rabbit pAb
-
Gene ID
816/818/817
-
SwissProt ID
Q13554/Q13555/Q13557
-
Gene Name
CAMK2B
-
Alternative Names
Calcium/calmodulin-dependent protein kinase type II beta chain; CaM kinase II beta subunit; CaM-kinase II beta chain; CAM2; CaMK-II beta subunit; CAMK2B; CAMKB; EC 2.7.1.123; EC 2.7.11.17; KCC2B; kinase CaMK2-beta
-
Background
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca2+/calmodulin-binding and autophosphorylation, and is involved in dendritic spine and synapse formation, neuronal plasticity and regulation of sarcoplasmic reticulum Ca2+ transport in skeletal muscle (PubMed:16690701).
In neurons, plays an essential structural role in the reorganization of the actin cytoskeleton during plasticity by binding and bundling actin filaments in a kinase-independent manner. This structural function is required for correct targeting of CaMK2A, which acts downstream of NMDAR to promote dendritic spine and synapse formation and maintain synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. In developing hippocampal neurons, promotes arborization of the dendritic tree and in mature neurons, promotes dendritic remodeling. Also regulates the migration of developing neurons (PubMed:29100089).
-
Research Field
Cell Biology
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse,Rat
-
Application
WB,IHC-P
-
Dilution Ratio
WB: 1/500-1/3000 IHC: 1/50-1/100
-
Molecular Weight
Calculated MW: 62 kDa
-
Clonality
Polyclonal Antibody
-
Isotype
IgG
-
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human CaMK2-β/γ/δ around the phosphorylation site of threonine 287 (Q-E-TP-V-E).
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Phosphorylated
-
Form
liquid
-
Buffer System
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.