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Product Name
Phospho-p70 S6 Kinase β (Ser423) Rabbit pAb
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Gene ID
6199
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SwissProt ID
Q9UBS0
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Gene Name
RPS6KB2
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Alternative Names
4 beta; 70 kDa ribosomal protein S6 kinase 2; EC 2.7.11.1; kinase p70S6K-beta; KS6B2; p70 ribosomal S6 kinase beta; p70 S6Kbeta; p70-S6KB; p70S6K-beta; Ribosomal protein S6 kinase beta 2; RPS6KB2; S6 kinase-related kinase; S6K-beta 2; S6K2; SRK; STK14B
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Background
Phosphorylates specifically ribosomal protein S6 (PubMed:29750193).
Seems to act downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression in an alternative pathway regulated by MEAK7 (PubMed:29750193).
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Research Field
Epigenetics and Nuclear Signaling
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse
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Application
WB
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Dilution Ratio
WB: 1/500-1/3000
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Molecular Weight
Calculated MW: 53 kDa
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Clonality
Polyclonal Antibody
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Isotype
IgG
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Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human p70 S6 Kinase β around the phosphorylation site of serine 423 (P-V-SP-P-L).
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
liquid
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Buffer System
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.