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Product Name
Phospho-PAK2 (Ser197) Rabbit pAb
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Gene ID
5062
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SwissProt ID
Q13177
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Gene Name
PAK2
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Alternative Names
EC 2.7.11.1; gamma-PAK; kinase PAK2; P21-activated kinase 2; p21-activated kinase 2; p21-activated protein kinase I; PAK 2; PAK-2; PAK65; PAKI; S6/H4 kinase
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Background
Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell motility, cell cycle progression, apoptosis or proliferation (PubMed:12853446, PubMed:16617111, PubMed:19273597, PubMed:19923322, PubMed:33693784, PubMed:7744004, PubMed:9171063).
Acts as a downstream effector of the small GTPases CDC42 and RAC1 (PubMed:7744004).
Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues (PubMed:7744004).
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Research Field
Cell Biology
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
IHC-P
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Dilution Ratio
IHC: 1/50-1/100
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Molecular Weight
Calculated MW: 58 kDa
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Clonality
Polyclonal Antibody
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Isotype
IgG
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Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human PAK2 around the phosphorylation site of serine 197 (T-R-SP-V-I).
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
liquid
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Buffer System
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.