-
Product Name
Phospho-EPS15 (Tyr849) Rabbit pAb
-
Gene ID
2060
-
SwissProt ID
P42566
-
Gene Name
EPS15
-
Alternative Names
AF-1P; AF1P; ALL1 fused gene from chromosome 1; epidermal growth factor receptor pathway substrate 15; Epidermal growth factor receptor substrate 15; EPS15; MLLT5; Protein AF-1p; Protein Eps15
-
Background
Involved in cell growth regulation. May be involved in the regulation of mitogenic signals and control of cell proliferation. Involved in the internalization of ligand-inducible receptors of the receptor tyrosine kinase (RTK) type, in particular EGFR. Plays a role in the assembly of clathrin-coated pits (CCPs). Acts as a clathrin adapter required for post-Golgi trafficking. Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR); internalization of ITGB1 as DAB2-dependent cargo but not TFR seems to require association with DAB2.
-
Research Field
Signal Transduction
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse,Rat
-
Application
WB
-
Dilution Ratio
WB: 1/500-1/3000
-
Molecular Weight
Calculated MW: 98 kDa
-
Clonality
Polyclonal Antibody
-
Isotype
IgG
-
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human EPS15 around the phosphorylation site of tyrosine 849.
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Phosphorylated
-
Form
liquid
-
Buffer System
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.