-
Product Name
Phospho-FRS2 (Tyr436) Rabbit pAb
-
Gene ID
10818
-
SwissProt ID
Q8WU20
-
Gene Name
FRS2
-
Alternative Names
FGFR signalling adaptor; FGFR signalling adaptor SNT-1; SNT-1; SNT2; SUC1-associated neurotrophic factor target; Suc1-associated neurotrophic factor target
-
Background
Adapter protein that links activated FGR and NGF receptors to downstream signaling pathways. Plays an important role in the activation of MAP kinases and in the phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, in response to ligand-mediated activation of FGFR1. Modulates signaling via SHC1 by competing for a common binding site on NTRK1.
-
Research Field
Signal Transduction
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse
-
Application
WB,IHC-P
-
Dilution Ratio
WB: 1/500-1/3000 IHC: 1/50-1/100
-
Molecular Weight
Calculated MW: 57 kDa
-
Clonality
Polyclonal Antibody
-
Isotype
IgG
-
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human FRS2 around the phosphorylation site of tyrosine 436 (L-N-YP-I-Q).
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Phosphorylated
-
Form
liquid
-
Buffer System
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.