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Product Name
Phospho-HER3 (Tyr1328) Rabbit pAb
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Gene ID
2065
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SwissProt ID
P21860
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Gene Name
ERBB3
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Alternative Names
c-erbB3; EC 2.7.10.1; ERB3; ERBB3; HER3; kinase ErbB3; Receptor protein-tyrosine kinase erbB-3 precursor; Tyrosine kinase-type cell surface receptor HER3
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Background
Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778).
May also be activated by CSPG5 (PubMed:15358134).
Involved in the regulation of myeloid cell differentiation (PubMed:27416908).
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Research Field
Tags & Cell Markers
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse,Rat
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Application
WB,IHC-P,ICC/IF
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Dilution Ratio
WB: 1/500-1/3000 IHC: 1/50-1/100 ICC/IF: 1/100-1/500
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Molecular Weight
Calculated MW: 148 kDa
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Clonality
Polyclonal Antibody
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Isotype
IgG
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Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human HER3 around the phosphorylation site of Tyr1328
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
liquid
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Buffer System
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.