-
Product Name
Phospho-Trk B (Tyr515) Rabbit pAb
-
Gene ID
4915
-
SwissProt ID
Q16620
-
Gene Name
NTRK2
-
Alternative Names
BDNF/NT-3 growth factors receptor precursor, EC 2.7.10.1, GP145-TrkB, GP145-TrkB/GP95-TrkB, NTRK2, Trk-B, TrkB tyrosine kinase, kinase TrkB
-
Background
Receptor tyrosine kinase involved in the development and the maturation of the central and the peripheral nervous systems through regulation of neuron survival, proliferation, migration, differentiation, and synapse formation and plasticity (By similarity).
Receptor for BDNF/brain-derived neurotrophic factor and NTF4/neurotrophin-4. Alternatively can also bind NTF3/neurotrophin-3 which is less efficient in activating the receptor but regulates neuron survival through NTRK2 (PubMed:15494731, PubMed:7574684).
Upon ligand-binding, undergoes homodimerization, autophosphorylation and activation (PubMed:15494731).
-
Research Field
Neuroscience
-
Product Categories
Primary antibody
-
Host
Rabbit
-
Reactivity
Human,Mouse,Rat
-
Application
WB,IHC-P
-
Dilution Ratio
WB: 1/500-1/3000 IHC: 1/50-1/100
-
Molecular Weight
Calculated MW: 91 kDa
-
Clonality
Polyclonal Antibody
-
Isotype
IgG
-
Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human Trk B around the phosphorylation site of tyrosine 515 (P-Q-YP-F-G).
-
Purification
Affinity Purified
-
Conjugation
Unconjugated
-
Modification
Phosphorylated
-
Form
liquid
-
Buffer System
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
-
Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.