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Product Name
Phospho-VE-Cadherin (Tyr731) Rabbit pAb
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Gene ID
1003
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SwissProt ID
P33151
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Gene Name
CDH5
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Alternative Names
7B4 antigen; CADH5; Cadherin-5; CD144 antigen; Vascular endothelial-cadherin precursor; VE-cadherin
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Background
Cadherins are calcium-dependent cell adhesion proteins (By similarity).
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (PubMed:21269602).
This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions (By similarity).
It associates with alpha-catenin forming a link to the cytoskeleton (PubMed:10861224).
Plays a role in coupling actin fibers to cell junctions in endothelial cells, via acting as a cell junctional complex anchor for AMOTL2 and MAGI1 (By similarity).
Acts in concert with KRIT1 and PALS1 to establish and maintain correct endothelial cell polarity and vascular lumen (By similarity).
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Research Field
Signal Transduction
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Product Categories
Primary antibody
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Host
Rabbit
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Reactivity
Human,Mouse
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Application
WB,IHC-P
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Dilution Ratio
WB: 1/500-1/3000 IHC: 1/50-1/100
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Molecular Weight
Calculated MW: 87 kDa
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Clonality
Polyclonal Antibody
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Isotype
IgG
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Immunogen
The antiserum was produced against synthesized phosphopeptide derived from human VE-Cadherin around the phosphorylation site of tyrosine 731 (H-I-YP-G-Y).
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Purification
Affinity Purified
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Conjugation
Unconjugated
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Modification
Phosphorylated
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Form
liquid
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Buffer System
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.