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Product Name
Wilms Tumor Protein (9D1) Mouse mAb
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Gene ID
7490
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SwissProt ID
P19544
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Gene Name
WT1
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Alternative Names
GUD; AWT1; WAGR; WT33; NPHS4; WIT-2; EWS-WT1;
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Background
Swiss-Prot Acc.P19544.
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Research Field
Tags & Cell Markers
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Product Categories
Primary Antibody
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Host
Mouse
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Reactivity
Human
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Application
IHC-P,WB
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Cited
Mouse
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Dilution Ratio
IHC-p: 1/100-1/500 WB: 1/500-1/2000
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Molecular Weight
Observed MW (kDa):55
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Clonality
Monoclonal antibody
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Clonality No.
9D1-8B8-4B8
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Isotype
Mouse IgG1, κ
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Immunogen
Synthesized peptide derived from human Wilms' Tumor 1(WT1)
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Purification
Affinity Chromatography
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Conjugation
Unconjugated
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Modification
Unmodification
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Form
Liquid
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Buffer System
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3.
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Storage
Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
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Cellular localization
Cytoplasm, Nucleus
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Gene Description
This gene encodes a transcription factor that contains four zinc-finger motifs at the C-terminus and a proline/glutamine-rich DNA-binding domain at the N-terminus. It has an essential role in the normal development of the urogenital system, and it is mutated in a small subset of patients with Wilms tumor. This gene exhibits complex tissue-specific and polymorphic imprinting pattern, with biallelic, and monoallelic expression from the maternal and paternal alleles in different tissues. Multiple transcript variants have been described. In several variants, there is evidence for the use of a non-AUG (CUG) translation initiation codon upstream of, and in-frame with the first AUG. Authors of PMID:7926762 also provide evidence that WT1 mRNA undergoes RNA editing in human and rat, and that this process is tissue-restricted and developmentally regulated. [provided by RefSeq, Mar 2015]